Knee osteoarthritis Musculoskeletal Diseases Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged between 50 and 75 years 2. Medial knee osteoarthritis according a radiographic grading of Kellgren/Lawrence (K/L) K/L 3 or K/L 4 3. Continuous knee pain lasting at least 6 months
Exclusion criteria
Exclusion criteria: 1. Lateral knee osteoarthritis 2. Patellofemoral osteoarthritis 3. Rheumatoides arthritis 4. Post-traumatic arthritis 5. Earlier osteotomy 6. Severe cardiovascular disease 7. Dementia 8. Urinary incontinence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Muscle power is measured using isokinetic device at baseline, 12 weeks and 6 to 8 months postsurgery 2. Knee symptoms are measured using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) at baseline, 12 weeks and 6 to 8 months postsurgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Muscle torque is measured using isokinetic device at baseline, 12 weeks and 6 to 8 months postsurgery 2. Thigh muscle cross-sectional area is measured using computed tomography at baseline, 12 weeks and 6 to 8 months postsurgery 3. Walking speed is measured using maximal 10 meter walk test at baseline, 12 weeks and 6 to 8 months postsurgery 4. Ability negotiating stairs is assessed by measured stair ascending and descending times at baseline, 12 weeks and 6 to 8 months postsurgery 5. Mobility and balance is measured using the 8-figure-run test at baseline, 12 weeks and 6 to 8 months postsurgery 6. Ability to get up from the chair is measured using the sit-to-stand test at baseline, 12 weeks and 6 to 8 months postsurgery 7. Mobility and balance is measured using the timed up and go test (TUG) at baseline, 12 weeks and 6 to 8 months postsurgery 8. Quality of life is measured using RAND 36-item health survey 1.0 at baseline, 12 weeks and 6 to 8 months postsurgery | — |
Countries
Finland