Effect of exogenous ketones as an adjunct to low-calorie diet on metabolic markers

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN97548466

Enrollment

Registered

2025-10-23

Start date

2019-03-01

Completion date

Unknown

Last updated

2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influencing weight loss with a low-calorie diet. Nutritional, Metabolic, Endocrine

Interventions

Study Procedures: Visit 1 (screening): • The experimental procedures used in the study will be communicated to subjects verbally and in writing. Subjects will have an opportunity to ask questions

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. BMI between 27 and 35 kg/m² 2. Stable weight (±2.3 kg in the previous 30 days) 3. Classified as normotensive (systolic <140 mmHg, diastolic <90 mmHg, resting heart rate <90 beats/min)

Exclusion criteria

Exclusion criteria: 1. Pregnancy, nursing 2. Any history of metabolic disease (e.g., diabetes, thyroid disorders), cardiovascular disease, hepatic or renal dysfunction, autoimmune or neurological conditions 3. Individuals taking dietary supplements or medications known to alter body weight, metabolism, or hormone levels within four weeks of study initiation

Design outcomes

Primary

Measure	Time frame
Body mass changes were measured using a dual-energy X-ray absorptiometry (DXA) scanner at the beginning and end of the study	—

Secondary

Measure	Time frame
Blood markers were measured using ELISA and dot blot at the beginning and end of the study	—

Countries

United States of America

Contacts

Public ContactBenjamin Bikman

bikman@byu.edu+18014221798

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026