Are the blood plasma adipokine and inflammatory marker concentrations different between obese and non-obese type 2 diabetes patients?

Plasma adipokine and inflammatory marker concentrations in obese and non-obese type 2 diabetes patients: an observational cross-sectional study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN97519965

Enrollment

Registered

2009-07-24

Start date

2008-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Non-insulin-dependent diabetes mellitus

Interventions

Overall, groups were matched for age and habitual physical activity (estimated by questionnaire). Additionally, non-obese type 2 diabetes patients and normoglycemic controls were matched for body mass

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: A total of 60 Caucasian males (aged between 40 and 75 years) are selected to participate in this study: 20 non-obese (body mass index [BMI] less than 30 kg/m^2) and 20 obese (BMI greater than 35 kg/m^2) type 2 diabetes patients, and 20 healthy, non-obese subjects (BMI less than 30 kg/m^2). Type 2 diabetes patients are diagnosed for at least 12 months prior to investigation and are all treated with oral blood glucose lowering medication. All subjects are sedentary and do not participate in any regular exercise program and/or caloric intake restriction intervention for at least 5 years.

Exclusion criteria

Exclusion criteria: 1. Type 1 diabetes patients 2. Females 3. Non-adult patients 4. Deregulated diabetes

Design outcomes

Primary

Measure	Time frame
Fasting blood samples are collected to compare the following between groups: 1. Adiponectin 2. Resistin 3. Leptin 4. Interleukin-6 5. High-sensitivity C-reactive protein 6. Tumour necrosis factor alpha 7. Free fatty acid concentrations Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.	—

Measure

Time frame

Fasting blood samples are collected to compare the following between groups: 1. Adiponectin 2. Resistin 3. Leptin 4. Interleukin-6 5. High-sensitivity C-reactive protein 6. Tumour necrosis factor alpha 7. Free fatty acid concentrations Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.

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Secondary

Measure	Time frame
Fasting blood samples are collected to compare the following between groups: 1. Glycosylated haemoglobin (HbA1c) content 2. Blood lipid profile 3. Insulin level 4. Homeostatic Model Assessment (HOMA) index 5. Fat-free mass 6. Whole-body oxygen uptake 7. Workload capacity Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.	—

Measure

Time frame

Fasting blood samples are collected to compare the following between groups: 1. Glycosylated haemoglobin (HbA1c) content 2. Blood lipid profile 3. Insulin level 4. Homeostatic Model Assessment (HOMA) index 5. Fat-free mass 6. Whole-body oxygen uptake 7. Workload capacity Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.

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Countries

Belgium

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026