Randomised crossover trial to determine whether a beta blocker and an Angiotensin Converting Enzyme (ACE) inhibitor have independent effects in lowering blood pressure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN97280940

Enrollment

Registered

2007-05-16

Start date

2004-04-14

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease Circulatory System Hypertension

Interventions

All participants received each of the following interventions: 1. Atenolol 25 mg 2. Lisinopril 5 mg 3. Atenolol 25 mg + lisinopril 5 mg 4. Placebo sequentially in a random sequence.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Men or women over age 40 2. Blood presssure over 100/60 mmHg

Exclusion criteria

Exclusion criteria: 1. Peripheral vascular disease 2. Asthma 3. Atrial Fibrillation (AF)

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic blood pressure.	—

Secondary

Measure	Time frame
Adverse effects.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026