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A study to improve the diagnosis of vertigo in general practice

The diagnostic accuracy of history taking and physical examination for patients with vertigo in general practice: the VERDI study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN97250704
Enrollment
960
Registered
2023-02-16
Start date
2023-03-01
Completion date
Unknown
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with a new episode of vertigo and/or episodic vestibular syndrome in general practice Signs and Symptoms Dizziness and giddiness

Interventions

First, the researchers will perform a systematic review (I) to assess the empirical evidence on diagnostic tests for patients with vertigo in general practice. The most promising tests will be studied

Sponsors

Amsterdam UMC Location VUmc
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 120 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and over 2. New episode of vertigo and/or episodic vestibular syndrome (definition: see below) 3. Presentation of symptoms during (telephone) consultation or home visit Definition of vertigo: The VERDI study will adopt the nomenclature of the Bárány society, the leading international organization for clinicians and researchers involved in vestibular medicine. The Bárány society previously realized the International Classification of Vestibular Disorders (ICVD), a uniform way to describe vestibular symptoms. The VERDI study will focus on patients with vertigo (defined by the ICVD as “the sensation of self-motion when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement”) and/or episodic vestibular syndrome (defined by the ICVD as “clinical syndrome of transient vertigo, dizziness, or unsteadiness lasting seconds to hours, occasionally days, and generally including features suggestive of temporary, short-lived vestibular system dysfunction”). When assessing a patient with vestibular symptoms, the Bárány society recommends focusing on timing (onset, duration, and evolution of symptom) and triggers (actions, movements, or situations that provoke the onset of symptoms. During the diagnostic accuracy study, the researchers will investigate the diagnostic value of timing, triggers, and other (individual and combinations of) items of history taking.

Exclusion criteria

Exclusion criteria: 1. Serious comorbid conditions that preclude participation in the VERDI study (judgement of patient’s GP) 2. Severe cognitive impairment (judgement of patient’s GP) 3. Insufficient mastery of Dutch and English language

Design outcomes

Primary

MeasureTime frame
Diagnostic accuracy is measured using sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and diagnostic odds ratios at a single timepoint

Secondary

MeasureTime frame
The methodological quality of diagnostic accuracy studies, measured using the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist at a single timepoint

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026