Radicular pain Signs and Symptoms Radicular pain
Conditions
Interventions
Participants are randomised to one of two groups using a single randomisation technique.
Intervention group: Participants receive Diosmin (Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd) per os, 9
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preliminarily diagnosis of radicular pain 2. Aged 18 years and over 3. Pain duration at least 30 days 4. Underwent routine discography 5. Previously treated with nonsteroidal anti-inflammatory drugs, opioid medications or physical therapy without pain relief for more than one month 6. Normal or slight decrease in the height of disc space on lateral plain X-ray film 7. Initially considered eligible for surgical intervention
Exclusion criteria
Exclusion criteria: 1. Spondylolysis 2. Lumbar canal stenosis 3. Isthmic or degenerative spondylolisthesis 4. Inflammatory arthritis 5. Spinal instability 6. Infection from previous lumbar surgery 7. Neurologic disease 8. Tumor 9. Psychological disorders (such as depression or using antidepressant/anxiolytic medications)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Perceived pain is measured using a visual analogue scale (VAS) and a numerical rating scale (NRS) just after the administration of drugs, and two and eight weeks later 2. Self-rated physical disability is measured using the Roland-Morris questionnaire (RM-Q) just after the administration of drugs, and two and eight weeks later | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient’s satisfaction is measured using a three-grade scale ranging from completely satisfied (no pain at all time and no restriction of activities) to satisfied (slight pain that requires no medication and mild restriction of activities) to unsatisfied (moderate to severe pain that requires medication and moderate to severe restriction of activities) via telephone after two years. | — |
Countries
China
Outcome results
None listed