Topic: Infection
Conditions
Interventions
Once a positive blood culture has been identified patients meeting the inclusion criteria will be randomised 1:1 to receive conventional diagnosis or rapid diagnosis. A web-based randomisation system
Sponsors
North Bristol NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 years and over 2. Male and female 3. Blood culture positive for bacteria or fungi 4. Admitted to hospital
Exclusion criteria
Exclusion criteria: 1. Less than 18 years of age 2. Patients on the end of life pathway when the blood sample was taken 3. Previously randomised for this study as each patient will only be recruited once 4. Prisoners or young offenders in the custody of HM Prison Service in England or Wales. 5. Patients not recieving NHS care 6. Attending physician deems patient unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the impact of laboratory based rapid diagnosis of Blood Stream Infections on 28-day all-cause mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the impact of rapid diagnosis on all-cause mortality at 7 days 2. To assess the impact of rapid diagnosis on resolution of infection, measured by temperature 3. To assess the impact of rapid diagnosis on patient length of stay (days) 4. To assess the impact of rapid diagnosis on acquisition of Clostridium difficile infection within 28 days 5. To assess the impact of rapid diagnosis on in-hospital antibiotic consumption in the first 7 days 6. To assess the impact of rapid diagnosis on the NHS costs and cost-effectiveness of acute care 7. To assess the impact of rapid diagnosis on time to initiation of appropriate antibiotic therapy and time to appropriate de-escalation of empirical broad-spectrum antibiotic therapy 8. To investigate the relationship between the timing of appropriate antibiotic therapy and clinical outcomes | — |
Countries
United Kingdom
Outcome results
None listed