Antimicrobial resistance effect on mortality Other
Conditions
Interventions
This will be a retrospective observational cohort study. Eligible patients will be identified through the Civil Registrations of Death database provided by NHS England and will be linked to the HES da
Sponsors
University College London
Eligibility
Sex/Gender
All
Age
0 Years to 150 Years
Inclusion criteria
Inclusion criteria: All patients who had their death registered in England between 01/01/2021 and 31/12/2023 will be included in this study.
Exclusion criteria
Exclusion criteria: Only patients who had expressed the wish for their data not to be used for research purposes under the National Data Opt-Out (DOO) will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured using clinical databases: The total number of patients with AMR-associated deaths in England in 2021-2023 | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured using clinical databases: 1. The percentage of AMR-associated deaths in 2021, 2022 and 2023, including the monthly trend of totals numbers. 2. The total number and percentage of AMR-associated deaths for each site of infection, AMR pathogen of interest, pathogen-drug combination, and resistance mechanism. 3. Underlying cause of death (UCODs) and Multiple cause of death (MCDs) groupings percentages for the entire study cohort. 4. The total number and percentage of UCOD and MCDs that were AMR-associated. 5. The total number and percentage of patients with AMR-associated deaths who die in hospital versus in the community. 6. The percentage of AMR-associated deaths per medical specialty for patients who died in hospital. 7. The association between AMR and healthcare utilisation (mode of admission, duration of stay in hospital, ICU admission rates and duration of stay, life-support duration). 8. The total number and percentage of patients with AMR pathogens of interest in sterile sites within 28 days of death without infection being recorded in the pathway that led to death in the MCCD. 9. The total number of patients who had AMR documented in their death certificate (by using the ICD-10 codes U82-84). | — |
Countries
England, United Kingdom
Contacts
Public ContactIoannis Baltas
Outcome results
None listed