Rapid versus slow rate advancement of feeds for enterally fed extremely low birth weight infants =1000g

Rapid versus slow rate advancement of feeds for enterally fed extremely low birth weight infants =1000g: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN96923718

Enrollment

200

Registered

2011-12-07

Start date

2011-09-08

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low birth weight Pregnancy and Childbirth Other low birth weight

Interventions

Randomised into four groups 1. Low volume initiation + slow advancement 2. Low volume initiation + rapid advancement 3. High volume initiation + slow a

Feeding will be initiated on the first day with 24ml/kg/d of EBM/DEBM, on day 2 the infant will receive 24ml/kg/d .Thereafter the feeds will be increased in increments of 24ml/kg/day until enteral fee

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All inborn infants less than or equal to 1000g

Exclusion criteria

Exclusion criteria: 1. All outborn infants 2. Congenital abnormalities which would preclude feeds or immediately life threatening

Design outcomes

Primary

Measure	Time frame
Time to attain 1500g weight	—

Secondary

Measure	Time frame
1. Clinical 1.1. Time to regain birth weight 1.2. Ttime to discharge 1.3. Mortality 1.4. Days nil by mouth 1.5. Necrotising enterocolitis (NEC) 1.6. Death before discharge 1.7. Growth in head circumference to discharge 1.8. Growth in length to discharge 1.9. The need for total parenteral nutrition (TPN) 2. Health services resource utilisation 2.1. Days of parenteral nutrition 2.2. Time to death or discharge	—

Measure

Time frame

1. Clinical 1.1. Time to regain birth weight 1.2. Ttime to discharge 1.3. Mortality 1.4. Days nil by mouth 1.5. Necrotising enterocolitis (NEC) 1.6. Death before discharge 1.7. Growth in head circumference to discharge 1.8. Growth in length to discharge 1.9. The need for total parenteral nutrition (TPN) 2. Health services resource utilisation 2.1. Days of parenteral nutrition 2.2. Time to death or discharge

—

Countries

South Africa

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026