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Reducing inappropriate antibiotic prescribing for acute respiratory tract infections using an antibiotic training and management program led by local hospitals in China

Reducing inappropriate antibiotic prescribing for acute respiratory tract infections through a comprehensive antibiotic stewardship in primary care facilities: a clustered randomised controlled trial and follow-up study in rural Guangdong, China

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN96892547
Enrollment
3400
Registered
2019-08-18
Start date
2020-03-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory tract infections, including acute upper respiratory tract infections and acute bronchitis Infections and Infestations

Interventions

Current interventions as of 12/02/2020: All recruited township hospitals will be stratified by county and be randomized into the intervention or control group in an overall 1:1 ratio with a 9:8 ratio

Sponsors

First Affiliated Hospital of Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0 Years to 75 Years

Inclusion criteria

Inclusion criteria: Healthcare professionals: 1. Physicians, pharmacists, radiologists and directors in enrolled township hospitals in two selected counties in Shaoguan City, Guangdong Province who agree to participate in the study Patient/caregivers: 1. Patients aged 0-75 years diagnosed with acute RTIs and/or their caregivers

Exclusion criteria

Exclusion criteria: Township hospitals: 1. Township hospitals that have participated in the pilot study Patients: 1. Non-acute RTI 2. Pneumonia 3. Chronic conditions including asthma, COPD, non-infective or non-acute disorders 4. Immunological deficiencies 5. Tuberculosis 6. Any form of cancer

Design outcomes

Primary

MeasureTime frame
Proportion of prescriptions for acute RTIs that contain any antibiotic. All primary and secondary outcomes will be collected from electronic medical records at baseline (12 months before intervention), intervention period (12 months) and long-term follow-up period (24 months after intervention).

Secondary

MeasureTime frame
Current secondary outcome measures as of 12/02/2020: 1. Broad-spectrum antibiotic prescription rate 2. Fluoroquinolones prescription rate 3. Prescription rate for multiple antibiotics 4. Intravenous injection antibiotic prescription rate 5. The proportion of prescriptions containing any antibiotics in the Access group of the WHO’s 2019 Essential Medicine List classification 6. The proportion of prescriptions containing any Traditional Chinese Medicines 7. The proportion of prescriptions containing any glucocorticoids 8. The average cost of a prescription 9. The average cost of a consultation Previous secondary outcome measures: 1. Broad spectrum antibiotic prescription rate 2. Prescription rate for broad spectrum antibiotics excluding amoxicillin-clavulanic acid 3. Prescription rate for multiple antibiotics 4. Intravenous injection antibiotic prescription rate 5. Prescription rate for alternative medicines 6. Average cost of a prescription All primary and secondary outcomes will be collected from electronic medical records at baseline (12 months before intervention), intervention period (12 months) and long-term follow-up period (24 months after intervention).

Countries

China

Contacts

Public ContactChao Zhuo
chao_sheep@263.net+8618928868397

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026