COVID-19 interstitial pneumonia Respiratory
Conditions
Interventions
The study will include patients with COVID-19 interstitial pneumonia documented with positive SARS-CoV-2 RT-PCR test result.
Single-center interventional randomized controlled trial.
Sponsors
Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. COVID-19 (positive RT-PCR test and interstitial pneumonia observed in CT scan), 2. Clinically severe interstitial pneumonia with respiratory failure / pre ARDS (MEWS classification of 3-4 points), 3. <90-92% SpO2 at rest 4. Consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Unstable ischemic heart disease, 2. Significant haemodynamic aortic stenosis, 3. Valve defects requiring surgical correction, 4. Complex ventricular arrhythmias, 5. Implantation of a cardiac pacemaker, cardioverter-defibrillator (ICD) and cardiac re-synchronizing pacemaker (CRT), 6. Acute myocarditis or pericarditis, 7. Uncontrolled hypertension, 8. End-stage renal disease and liver failure disease, 9. Lack of consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life in COVID-19 patients assessed with the Polish version of the CAT questionnaire at baseline and after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Selected respiratory (gasometric) indicators measured by SpO2 pulse oximeter at baseline and after treatment. 2. Laboratory indicators (TNF, sTNFR1, IL-6, IL-10, d-dimers, CRP) measured by laboratory blood tests at baseline and after treatment. | — |
Countries
Poland
Outcome results
None listed