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AVAPS in Acute Respiratory Failure of various etiologies

Non-Invasive mechanical Ventilation with pressure support guaranteed with average volume (AVAPS) in Acute Respiratory Failure of various etiologies

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN96455367
Enrollment
68
Registered
2017-07-19
Start date
2010-12-01
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patients were divided according to the pathology on the basis of which presented the acute respiratory failure: COPD / bronchial asthma / pneumonia / ARDS / congestive heart failure and interstitial disease Circulatory System Acute respiratory failure

Interventions

Participants are allocated to groups based on their type of acute respiratory failure: Hypercapnic ARF: Obstructive diseases (COPD and bronchial asthma) Hypoxemic ARF: Pneumonia, ARDS, congestive he

Sponsors

The University of Guayaquil (Universidad de Guayaquil)
Lead Sponsor
Universidad San Francisco de Quito
Collaborator
University of Guayaquil
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and over 2. Admitted to the intensive care unit of Santa Maria Clinic 3. Acute respiratory failure due to exacerbation of COPD, asthma, pneumonia, ARDS, congestive heart failure and intestitial lung disease

Exclusion criteria

Exclusion criteria: 1. Facial deformity 2. Obstruction of the upper airway by surgery or trauma 3. Alterations in the central nervous system does not relating to hypercapnic encephalopathy 4. Cardiogenic pulmonary edema, pulmonary embolism, pneumothorax, hemoptysis, or septic shock 5. Urgent intubation due to cardiorespiratory arrest and hemodynamic instability with systolic pressure less than 80 mm Hg. 6. Hemodynamic instability 7. Excess of respiratory secretions 8. Non-cooperative or agitated 9. Unable to use the interface device 10. Has had recent surgery of the upper airway, 11. Received NIV with “Do not resuscitate orders"

Design outcomes

Secondary

MeasureTime frame
1. Days of hospitalisation is measured using patient records at number of discharge 2. Number of endotrachael intubation is measured using patient records at number of intubated patients and their percentage at discharge 3. Death is measured using patient records at time of death

Primary

MeasureTime frame
1. Use of NIV is measured using patient records at discharge from hospital 2. Aterial blood gas is measured using an arterial blood gas test (blood test) at baseline, one, 12 and 24 hours of NIV use 3. Severity of disease is measured using the APACHE II (Acute Physiology and Chronic Health Evaluation (APACHE II ) score at range (0-71 points) 4. Blood pressure (mm/Hg) is measured using a blood pressure cuff 5. Heart rate is measured using pulse monitors 6. Respiratory rate is measured using the amount of breaths over one minute. 7. Tidal volume (mL) programmed AVAPs is measured using patient records. 8. Levels of IPAP (cmH2O) are measured using patient records 9. Level of EPAP (cmH2O) are measured using patient records 10. Inspiratory time (mseg) is measured using patient records 11. Tidal volume patients (mL) is measured using patient records 12. Radiographic changes are measured at number quadrant divided into four according to the affection 13. Complications (excessive discomfort, nasal ulcer, gastric distension and claustrophobia) are measured using patient records

Countries

Ecuador

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026