Bacterial meningitis Nervous System Diseases Bacterial meningitis, not elsewhere classified
Conditions
Interventions
Participants will be recruited from the triage assessment area if they meet the inclusion criteria by a study nurse.
The duration of the intervention will be 6 hours from initial screening to the poi
Sponsors
Liverpool School of Tropical Medicine (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Screening inclusion criteria 1. 1. All adults > 12 years presenting to the adult emergency trauma centre with fever plus one of headache/convulsions/confusion/neck stiffness (Note: In Malawi the cut off for paediatric medicine is 50 cells/mm2, irrespective of human immunodeficiency virus (HIV) status, or visible bacteria in the counting chamber
Exclusion criteria
Exclusion criteria: 1. Screening exclusion criteria 1.1. Known terminal disease 1.2. Head injury 1.3. Proven cerebral malaria 2. Final exclusion criteria 2.1. CSF culture, antigen test or stain for fungal or mycobacterial organisms, or CSF <100 cells/mm3 HIV negative or CSF <5 cells/mm3 HIV positive, or a CSF WCC <50% neutrophils
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of targets achieved by the care bundle measured 6 hours from the care bundle initiation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mortality 2. Seizure frequency 3. Neurological disability at follow up Measured at day 10 of discharge from hospital and day 40 follow-up in the community for survivors. | — |
Countries
Malawi
Outcome results
None listed