Low bone mass/risk of osteoporosis Musculoskeletal Diseases Osteoporosis
Conditions
Interventions
This is a 15-month observational study starting in March 2006 aiming to assess how diet and sunlight exposure influence vitamin D status for each three-monthly season. There will be five visits in tot
Sponsors
Food Standards Agency (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women from a previous sceening study (Aberdeen Prospective Osteoporosis Screening Study - APOSS) aged less than 65 years.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they: 1. Have chronic gastro-intestinal disease associated with malabsorption 2. Are taking oral corticosteroids 3. Are receiving bisphosphonate therapy (as there is a possibility of interaction with vitamin D metabolism)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Monitor longitudinally the seasonal variation in vitamin D status at a northerly latitude, assessing the individual contributions of sunlight and diet. All primary and secondary outcomes were measured at each visits, i.e., at Baseline (BL), 3-month, 6-month, 9-month and 12-month visits. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Monitor seasonal variation in physical activity (confounder of vitamin D status) 2. Monitor seasonal variation in: 2.1. Markers of bone turnover (functional marker) 2.2. Falls, muscle strength (functional markers not related to bone health) 3. Determine the relationship between vitamin D status, functional markers (Bone Mineral Density [BMD], bone resorption, muscle strength) with and without adjustment for physical activity level All primary and secondary outcomes were measured at each visits, i.e., at Baseline (BL), 3-month, 6-month, 9-month and 12-month visits; BMD was measured at 6-month and 9-month visits only. | — |
Countries
United Kingdom
Outcome results
None listed