Type one diabetes mellitus Nutritional, Metabolic, Endocrine Insulin-dependent diabetes mellitus
Conditions
Interventions
Subjects were randomised to receive:
1. 1 g ascorbic acid two hours prior to exercise
2. Placebo two hours prior to exercise
Supplementation took place once only for both treatment groups, and the fo
Sponsors
University of Glamorgan (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Diabetic volunteers were recruited from the adult diabetic clinic at the University Hospital of Wales, based on the following inclusion criteria: 1. Males aged 18 - 30 years 2. Glycosylated haemoglobin (HbA1c) of between 7 - 10% 3. Microalbuminuria negative 4. No underlying vascular complications Non-diabetic control subjects were recruited from the student population of the University of Glamorgan, based on the following inclusion criteria: 1. Matched for age 2. Matched for fitness 3. No metabolic or circulatory medical condition 4. Had no family history of diabetes as confirmed via interview and medical history questionnaire
Exclusion criteria
Exclusion criteria: 1. Cardiovascular disease 2. Hypertension 3. Any other known cardiac complication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Free radical species in human blood, measured before supplementation, two hours after supplementation (before exercise) and immediately after exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical markers such as lipid hydroperoxides, vitamin C and vitamin E, measured before supplementation, two hours after supplementation (before exercise) and immediately after exercise. | — |
Countries
United Kingdom
Outcome results
None listed