A randomised double blind placebo controlled study to evaluate the effectiveness of purified d-Limonene as an agent to relieve the symptoms of indigestion and "heartburn"

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN96109983

Enrollment

Registered

2007-08-16

Start date

2000-09-01

Completion date

Unknown

Last updated

2021-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal discomfort (indigestion/heartburn) Digestive System Gastrointestinal discomfort

Interventions

Participants were randomised to ten (10) capsules of d-Limonene or placebo and instructed to take capsules orally and report symptom relief as instructed on provided questionnaire daily.

Eligibility

Inclusion criteria

Inclusion criteria: Adults over 18 years of age who have experienced symptoms of indigestion and/or heartburn for at least six months.

Exclusion criteria

Exclusion criteria: 1. Known sensitivity to citrus products or by products 2. Known sensitivity to soy bean oil 3. History of gastrointestinal bleeding or ulcers 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
Relief of symptoms as reported subjectively by study participants daily for twenty days. Participants rated their symptom relief on the original questionnaires to day 20.	—

Secondary

Measure	Time frame
Continued relief of symptoms after completing 10 capsules. A follow up questionnaire was sent out at the six month time-point for feedback on continued relief of symptoms.	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026