Cocaine use disorder Mental and Behavioural Disorders
Conditions
Interventions
The study is a prospective, single-group longitudinal case-series intervention study. Eligible adults with DSM-5-TR cocaine use disorder are enrolled into one treatment arm and receive Process-Based C
Sponsors
University of Malta
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older 2. Meet DSM-5-TR diagnostic criteria for cocaine use disorder 3. Have cocaine use disorder as their primary substance use disorder 4. Have stable mental health status, including previous mental health problems that are in remission or stable on treatment 5. Have adequate cognitive and executive functioning to engage with the intervention
Exclusion criteria
Exclusion criteria: 1. A primary substance use disorder other than cocaine use disorder 2. Severe alcohol use disorder 3. An acute psychiatric condition at assessment, such as psychosis, severe depressive episode, active suicidality or mania 4. Diagnosed intellectual developmental disorder 5. Significant cognitive impairment 6. Severe comorbid substance use disorder requiring specialised treatment 7. Clinical needs exceeding the scope of the PB-CBH intervention or requiring urgent psychiatric care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cocaine use frequency, assessed by the number of days of cocaine use during the preceding 14-day period, measured using a modified Timeline Followback (TLFB) daily substance use log at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3) | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychological flexibility measured using the total score on the Comprehensive Assessment of Acceptance and Commitment Therapy Processes, 10-item version (CompACT-10), at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3);Autonomous functioning measured using the total score on the Index of Autonomous Functioning (IAF) at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3);Self-regulation measured using the total score on the Short Self-Regulation Questionnaire (SSRQ) at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3);Inhibitory control measured using the number of correct responses and/or interference performance on incongruent colour-word trials in Stroop task performance at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3);Attention and working memory measured using Digit Span Forward and Backward scores in Digit Span task performance at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3);Cocaine use disorder symptom severity, assessed via the number of DSM-5-TR cocaine use disorder criteria met, measured using a structured clinical evaluation at baseline/pre-intervention (T1), post-intervention (T2), and 3-month follow-up (T3) | — |
Countries
Malta
Contacts
Public ContactAnthony Dimech
Outcome results
None listed