Randomised controlled trial for the prevention of first variceal bleeding in cirrhotic patients with contraindications or intolerance to B-blockers (ligation versus no treatment)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN95937358

Enrollment

214

Registered

2003-09-12

Start date

1999-12-12

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Variceal bleeding Circulatory System Varicose veins of other sites

Interventions

A randomised controlled trial was designed, which will include cirrhotic patients with endoscopically documented varices and contraindications or intolerance to beta-blockers. Patients will be recruit

Eligibility

Inclusion criteria

Inclusion criteria: 214 cirrhotic patients with contraindications to receive beta-blockers

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

Measure	Time frame
To compare in a randomised controlled trial whether endoscopic variceal ligation (EVL) therapy reduces the risk of first variceal bleeding compared to no-therapy and improves chances of survival in cirrhotic patients with contraindication or intolerance to B-blockers.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026