Efficacy of mouth-rinses in reducing SARS CoV-2 viral load in the saliva of COVID-19 positive patients

Evaluating the comparative efficacy of virucidal mouth-rinses in reducing SARS-CoV-2 viral load in saliva as a pre-procedural prophylactic strategy in healthcare settings

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN95933274

Enrollment

Registered

2020-09-09

Start date

2020-06-30

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) Infections and Infestations

Interventions

The subjects are randomly allocated to three mouth-rinse groups, namely povidone-iodine (PI), chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC) and water control group.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Laboratory-confirmed COVID-19-positive patients

Exclusion criteria

Exclusion criteria: 1. History of allergy to PI, CPC or CHX and its relevant excipients 2. All forms of thyroid disease or current radioactive iodine treatment 3. Lithium therapy 4. Known pregnancy 5. Renal failure

Design outcomes

Primary

Measure	Time frame
Salivary CT values of SARS CoV-2 measured using reverse-transcription polymerase chain reaction (RT-PCR) at baseline, 5 min, 3 h and 6 h	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Singapore

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 24, 2026