Breast cancer Cancer Breast
Conditions
Interventions
The control arm receive standard breast irradiation (40-50 Gy) over 3-6 weeks and the experimental group receive no breast irradiation. All eligible patients are to receive some form of endocrine ther
Sponsors
University of Edinburgh (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Breast conserving surgery with a complete pathological excision margin of all invasive and non invasive cancer (a minimum of 1 mm on histological assessment) 2. Histologically confirmed unilateral breast cancer of pathological size 3 cm or less 3. Oestrogen receptor or progesterone receptor positive and treated with post-operative adjuvant endocrine therapy (patients who have been treated with pre-operative neo-adjuvant endocrine therapy can be included) 4. No axillary node involvement on histological assessment 5. Medically suitable to attend for all treatment and follow up 6. Able and willing to give informed consent
Exclusion criteria
Exclusion criteria: 1. Age younger than 65 years (date of issue of pathology results) 2. Grade III cancer combined with lymphatic/vascular invasion 3. Previous in situ or invasive carcinoma of either breast 4. Current or previous malignancy, within the past 5 years, other than non-melanomatous skin cancer or carcinoma in situ of cervix
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ipsilateral breast cancer recurrence rates | — |
Secondary
| Measure | Time frame |
|---|---|
| Regional recurrence, contralateral breast cancer, distant metastases, disease free survival and overall survival | — |
Countries
Scotland, United Kingdom
Outcome results
None listed