Use of PDE inhibitors for endometrial growth

PDE inhibitors and endometrial growth under clomiphene ovarian stimulation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN95746843

Enrollment

Registered

2015-08-11

Start date

2014-09-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Poor endometrial growth. Pregnancy and Childbirth

Interventions

Patients will be randomized according to previously sealed envelopes in order to start with Cycle A or Cycle B. 1. Cycle A: patients will receive clomiphene citrate 100 mg/day from th

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Infertile patients candidates to clomiphene ovarian stimulation 2. Female 3. 18 to 42 years old

Exclusion criteria

Exclusion criteria: 1. Smoking 2. Arterial hypertension 3. Prior uterine surgery

Design outcomes

Primary

Measure	Time frame
Endometrial growth, using ultrasound scans at day 4, 8 and 10.	—

Secondary

Measure	Time frame
1. Uterine artery pulsatility index 2. Uterine artery resistant index Measured by ultrasound on Day 4, 8 and 10.	—

Countries

Mexico

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026