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High versus low load training in females

The effect of high load versus low load resistance training and protein type on muscle mass and strength in females

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN95727228
Enrollment
52
Registered
2025-05-01
Start date
2025-05-05
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistance exercise and protein feeding Other

Interventions

This is a 2 x 2 nested factorial RCT where participants will be randomized to a training intervention (higher or lower load) and then randomized within each arm to receive either whey or casein protei

Sponsors

McMaster University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Between the ages of 18-35 years (inclusive) 2. Able to maintain a habitual diet and perform RET three times per week throughout the trial 3. Able to begin exercise (assessed by Get Active Questionnaire [GAQ]) 4. Understand the study procedures and sign this form providing informed consent to participate in the study

Exclusion criteria

Exclusion criteria: 1. Use of tobacco- or cannabis-related products (smoking or vaping) 2. A history of neuromuscular problems or muscle and/or bone-wasting diseases 3. Any acute or chronic illness; cardiac, pulmonary, liver, or kidney abnormalities; insulin- or non-insulin-dependent diabetes or other metabolic disorders (all ascertained through medical questionnaires) 4. Use of medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatory drugs (prescription use or daily use of over-the-counter medication), or prescription strength acne medications) 5. Have any electronic medical or metal implants 6. Currently pregnant or planning to get pregnant 7. Dairy allergy

Design outcomes

Primary

MeasureTime frame
Skeletal muscle mass assessed by D3-Cr-measured muscle mass at baseline and 10 weeks

Secondary

MeasureTime frame
Lean body mass: 1. Dual-energy x-ray absorptiometry (DXA)-measured lean body mass at baseline and 10 weeks. Muscle strength: 2. One repetition-maximum on a leg press machine and biceps curl measured at baseline, 5 and 10 weeks 3. Unilateral isometric maximum voluntary contraction of knee extension/elbow flexion measured at baseline and 10 weeks

Countries

Canada

Contacts

Public ContactDerrick Van Every
vaneverd@mcmaster.ca+1 (0)905 525 9140 Ext. 21918

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026