Evaluation of motor function in patients having surgery with or without intraoperative monitoring for motor eloquent braintumours. Surgery
Conditions
Interventions
Patients will undergo a clinical neurological examination prior to surgery which will include MCRS, NIHSS, six-spot-step test, 9-hole peg test, hand dynamometer, 10 timed walk test. Their surgery will
Sponsors
Odense University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over the age of 18 years 2. Indication for resection of contrast enhancing lesion in MRI (HGG/GBM, MET) 3. Intention to reach either GTR or CRET 4. Motor eloquence defined as closer than 20mm to either the CST (measured in preoperative DTI) or to the precentral gyrus
Exclusion criteria
Exclusion criteria: 1. Vulnerable persons such as pregnant woman or children 2. Emergency cases 3. Tumors involving both hemispheres
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Extent of resection (EOR) of contrast enhancing lesion (absolute and relative volume) on early postoperative MRI (24-48h) 2. Change in motor function (measured in MCRS, NIHSS, six-spot-step test, 9-hole peg test, hand dynamometer, 10 timed walk test, patients' global impression of change), 24 hours post op and 1 month post op. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Seizure history (change in Engel classification or antiepileptic drugs (AED)) after 1 month 2. Functional impairment measured using the Karnofsky performance scale at baseline and 1 month 3. Completeness of resection of fluorescein under the microscope judged by the surgeon at time of surgery 4. Surgeons impression on usefulness of intraoperative guidance at time of surgery | — |
Countries
Denmark
Outcome results
None listed