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Promoting rational antibiotic therapy in German primary care

Promoting rational antibiotic therapy among high antibiotic prescribers in German primary care (ElektRA). A 4-arm cluster-randomised controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN95468513
Enrollment
7250
Registered
2022-07-22
Start date
2022-09-01
Completion date
Unknown
Last updated
2023-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory and urinary tract infections Infections and Infestations

Interventions

Three interventions against the control group are tested: (A) personalised feedback on own prescribing behaviour in comparison to GPs of the region within a visual attention-grabbing graph (social nor
(B) feedback like (A) plus a project's own online training (eLearning) on rational prescribing practice and communication strategies
(C) feedback like (A) plus an online peer-moderated training in quality circle format on the topic of rational antibiotic prescribing, communication strategies and development of individual starting p
the total duration of follow up is 15 months. Randomisation into four groups (control group and three intervention arms A-C) will be stratified by regional Associations of Statutory H

Sponsors

Association of Substitute Health Funds (Vdek) e.V.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. General practitioners (GP) 2. Registered as physician with the "Association of Statutory Health Insurance Physicians" located in Baden-Wuerttemberg, Bavaria, Bremen, Hesse, Lower Saxony, North Rhine, Saarland, Schleswig-Holstein, Westphalia-Lippe 3. Prescription sum score >2 (sum score ranges from 0 to 6; a GP or GP practice obtains one or two points if its own value in one of the following aspects exceeds the 75% percentile of antibiotic prescribing within the respective region: 3.1. Overall prescription rate (ratio of patients with antibiotic prescriptions to patients with any prescription), one point 3.2. Prescription rate for upper respiratory tract infections (ratio of patients with upper respiratory tract infection to antibiotic prescriptions for these patients), one point 3.3. Prescription rate for lower respiratory tract infections (ratio of patients with lower respiratory tract infection to antibiotic prescriptions for these patients), one point 3.4. Prescription rate of fluoroquinolones; two points: Total prescription rate of fluoroquinolones (ratio of patients with fluoroquinolone to patients with antibiotic) and/or fluoroquinolone prescription rate for urinary tract infection (ratio of urinary tract infection patients with fluoroquinolone to urinary tract infection patients with antibiotics 3.5. Prescription rate of cephalosporins (ratio of patients with cephalosporin to patients with antibiotic); one point

Exclusion criteria

Exclusion criteria: Participation on the predecessor project RESIST

Design outcomes

Primary

MeasureTime frame
Physicians' overall rate of antibiotic prescriptions, measured as the proportion of patients with antibiotic prescriptions out of all patients with a prescription before intervention and after it starts

Secondary

MeasureTime frame
Physicians' overall prescription rates before and after the intervention for cephalosporins and fluoroquinolones separately

Countries

Germany

Contacts

Public ContactMaike Schulz
mschulz@zi.de+49 30 4005-2458

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 11, 2026