Colon cancer detection by measuring DNA of cells collected from rectum: A case-control study

Colorectal cancer screening by quantitative analysis of DNA isolated from exfoliated cells sampled from the surface of human rectal mucosa: A case-control study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN95403112

Enrollment

170

Registered

2008-07-16

Start date

2006-05-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer Cancer Malignant neoplasm of colon

Interventions

This study was conducted with two distinct groups of participants: 1. Patients with clinical diagnosis of colorectal malignancies 2. Clinically healthy volunteers In this case-control study both ca

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Case group: Consecutive patients (both males and females) with clinical diagnosis of colorectal malignancies recruited by Colorectal Surgery Department of the John Radcliffe Hospital (Oxford, UK) 2. Control group: Clinically healthy volunteers (both males and females), age 50-70, recruited by Honiton Hospital (Honiton, UK)

Exclusion criteria

Exclusion criteria: 1. For both case and control groups: Extensive surgical interventions in the colorectal region or colorectal malignancies in the past 2. For control group: Chronic colorectal conditions (even asymptomatic)

Design outcomes

Primary

Measure	Time frame
DNA yields from exfoliated materials (DNA scores) are assessed in terms of their predictive value in detecting the presence of colorectal cancer	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026