Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian meta-analysis of multiple N-of-1 clinical trials

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN95255919

Enrollment

Registered

2006-07-14

Start date

1999-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Juvenile idiopathic arthritis Musculoskeletal Diseases Juvenile idiopathic arthritis

Interventions

Amitriptyline 25 mg every hour of sleep (qhs) for two weeks per treatment period versus placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 10-18 years of age 2. Polyarticular course juvenile idiopathic arthritis 3. At least one active joint 4. Minimum pain score of 1 cm

Exclusion criteria

Exclusion criteria: Prolonged QT interval

Design outcomes

Primary

Measure	Time frame
Pain (measured with 6-10 cm visual analogue scale [VAS] over two days)	—

Secondary

Measure	Time frame
1. Sleep 2. Stiffness 3. Physical function 4. Active and swollen joint counts 5. Fatigue	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026