Pre-eclampsia Pregnancy and Childbirth
Conditions
Interventions
Participants will enrol via the secure online REDCap platform. After consenting, they will access a structured online form with seven essential demographic and clinical questions and then a 45-item fo
Sponsors
University of Liverpool
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Cases: 1. Currently pregnant women, with pre-eclampsia diagnosed according to NICE guidelines (the NICE diagnostic criteria are hypertension [>140/>90 mmHg] and proteinuria/renal insufficiency/liver involvement/neurological complications/haematological complications/uteroplacental dysfunction) attending Liverpool Women’s Hospital 2. Able to consent to the study in English Controls: 1. Currently pregnant, gestationally matched women without pre-eclampsia attending Liverpool Women’s Hospital 2. Able to consent to the study in English
Exclusion criteria
Exclusion criteria: Cases 1. Not a patient of Liverpool Women’s Hospital 2. Unable to consent in English Controls 1. Not a patient of Liverpool Women’s Hospital 2. Unable to consent in English 3. Past medical history making them at high risk of pre-eclampsia including chronic hypertension, gestational hypertension, chronic kidney disease, autoimmune diseases 4. Previous pregnancy history making them at high risk of pre-eclampsia including fetal growth restriction, small for gestational age fetus, hypertension in pregnancy, previous pre-eclampsia 5. Current pregnancy risk factors for pre-eclampsia: PAPP-A less than 5th Centile, echogenic bowel, estimated fetal weight less than 10th centile
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Ergothioneine intakes will be measured using a short, validated food frequency questionnaire, which asks participants how frequently (portions per day or week) they consumed typical foods in the last month. Ergothioneine intake will be estimated from reported consumption frequencies of ergothioneine-rich foods (e.g., mushrooms, fermented foods) using nutrient composition data. 2. Dietary quality will be measured using a short, validated Food Frequency Questionnaire (FFQ), which asks participants how frequently (portions per day or week) they consumed typical foods in the last month. Dietary quality is derived from the FFQ responses using a standardised 0–5 scoring system, where optimal intakes receive the highest score. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Dietary nutrient intakes will be measured using a 24-hour dietary recall using the MyFood24 Online Dietary Assessment Tool to capture participants’ most recent nutrient intakes daily 2. Participant feedback on the usability and acceptability of the Food Frequency Questionnaire (FFQ) will be measured at the point of survey using a self-administered feedback questionnaire that combines Likert-scale and open-ended questions | — |
Countries
England, United Kingdom
Contacts
Public ContactAslihan Özdemir
Outcome results
None listed