Schizophrenia Mental and Behavioural Disorders Schizophrenia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with schizophrenia spectrum disorder 2. Current or prior delusional symptoms 3. Informed consent 4. Clinical stability
Exclusion criteria
Exclusion criteria: 1. Age beyond 65 2. Severe brain damage 3. Intelligence Quotient (IQ) less than 70 4. More than or equal to five for ratings on hostility and non-cooperativeness and more than or equal to six on suspiciousness according to Positive And Negative Symptoms Scale (PANSS) interview 5. Incapacity to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 01/11/2012: A delusion score derived from the Positive and Negative Syndrome Scale (PANSS): sum score of items p1 (delusions), p5 (grandiosity) and p6 (suspiciousness) Previous primary outcome measures until 01/11/2012: 1. Decline on PANSS positive subscale from T1 (baseline) to T2 (four weeks/assessment immediately after the end of intervention) 2. Conventional algorithm (i.e., sum of PANSS positive items one to seven) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improvement of dysfunctional metacognitive biases (i.e., self-serving bias, jumping to conclusions bias, incorrigibility, over-confidence in errors, enhanced need for closure) 2. Subsequent to intervention represents secondary outcome parameter (i.e., difference T1-T2) Secondary analyses will include follow-up. | — |
Countries
Germany