Platelet recovery following donation Haematological Disorders Thrombocytopenia, unspecified
Conditions
Interventions
The donors will have bloods taken pre and post donation and at another four timepoints over the next 2 weeks.
Sponsors
NHS Blood and Transplant Trust Fund (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Male platelet donors aged over 18 who are able to donate on Monday or Tuesday morning
Exclusion criteria
Exclusion criteria: 1. Female donors 2. HPA-1a-5b negative donors who are used to maintain the supply of platelets for treatment of neonatal alloimmune thrombocytopenia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study will be the accurate measurement of the platelet count, the platelet volume and the quantity of newly formed platelets in platelet apheresis donors at the time of donation and at early (4-8 hours) and late (day 1, 3, 7 and 14) time points after donation. From the same blood sample used to look at the platelet count, the plasma will be isolated and analysed by mass spectrometry to identify which proteins contained in the blood promote new platelets release from the bone marrow. | — |
Secondary
| Measure | Time frame |
|---|---|
| Platelet donors give a donation every 4 weeks. Samples will be taken from established platelet donors and from newly recruited donors to establish whether the platelet count recovery and plasma proteins are different when platelet donations are done frequently. | — |
Countries
United Kingdom
Outcome results
None listed