Is hydrogen water intervention and cognitive-behavioral group therapy effective in women suffering from panic attacks?

Possible inflammatory response in anxiety disorders. Effects of psychological treatment and hydrogen water in women with panic disorder from the perspective of the gut-brain-microbiota axis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN95058526

Enrollment

Registered

2021-09-10

Start date

2018-09-14

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety disorder and associated inflammatory response in women with anxiety attacks from the perspective of the gut-brain-microbiota axis Mental and Behavioural Disorders

Interventions

The present study consists of a clinical sample of women with panic disorder, drawn from a total of five psychological treatment groups. At each initiation of group therapy, participants who meet the

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Participants have to meet the diagnostic criteria for panic disorder according to ICD-10 (F41.0) 2. Over 18 years old and under 65 years old 3. Attend a minimum of eight group sessions 4. Cannot have another mental disorder 5. Consume a minimum of a liter and a half of water daily 6. Cannot consume glucocorticoids or any type of drug that affects the immune and endocrine system 7. They cannot have night work hours that affect the circadian rhythm 8. Not have serious diseases such as cancers, heart disease, digestive system, viral infections 9. Not have oral diseases, inflammations or injuries that could cause oral bleeding.

Exclusion criteria

Exclusion criteria: 1. Women diagnosed with a gastrointestinal disease 2. Women receiving psychological treatment 3. Women with anxiety scores lower than the clinical mean 4. Drug or alcohol abuse 5. Women with severe psychiatric disorder

Design outcomes

Primary

Measure	Time frame
Measured before and after treatment: 1. Anxiety is measured with the State-Trait Anxiety Inventory (STAI). 2. Stress assessment is measured with the Perceived Stress Scale (PSS). 3. Depression is measured with the Depression Inventory (Beck-II). 4. Gastrointestinal symptoms are measured with the Gastrointestinal Symptom Rating Scale (GSRS). 5. Health-related quality of life is measured with the Health Questionnaire (SF-36v2). 6. The inflammatory response is measured with the analysis of cortisol in saliva and the analysis of proinflammatory cytokines IL-1ß, IL-6, IL-8, IL-12, IFN-?, and TNF-a.	—

Measure

Time frame

Measured before and after treatment: 1. Anxiety is measured with the State-Trait Anxiety Inventory (STAI). 2. Stress assessment is measured with the Perceived Stress Scale (PSS). 3. Depression is measured with the Depression Inventory (Beck-II). 4. Gastrointestinal symptoms are measured with the Gastrointestinal Symptom Rating Scale (GSRS). 5. Health-related quality of life is measured with the Health Questionnaire (SF-36v2). 6. The inflammatory response is measured with the analysis of cortisol in saliva and the analysis of proinflammatory cytokines IL-1ß, IL-6, IL-8, IL-12, IFN-?, and TNF-a.

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Secondary

Measure	Time frame
Measured at the beginning of the study: 1. Registration of variables through an interview: general sociodemographic data, data on habits and lifestyle, data on the history of physical illnesses, data on the consumption of antibiotics, psychotropic drugs and drugs for medical conditions, data on the type of diet. 2. Record of variables for the collection of biological samples: time of awakening, hours of sleep, spontaneous awakening or with an alarm clock, follicular phase, exact time of taking the samples.	—

Measure

Time frame

Measured at the beginning of the study: 1. Registration of variables through an interview: general sociodemographic data, data on habits and lifestyle, data on the history of physical illnesses, data on the consumption of antibiotics, psychotropic drugs and drugs for medical conditions, data on the type of diet. 2. Record of variables for the collection of biological samples: time of awakening, hours of sleep, spontaneous awakening or with an alarm clock, follicular phase, exact time of taking the samples.

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Countries

Spain

Contacts

Public ContactAna Belén Fernández Serrano

abfernandez2@alu.ucam.edu+34 655468000

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026