Colorectal cancer Cancer Malignant neoplasm of rectosigmoid junction
Conditions
Interventions
1. Perfusion computed tomography (CT) sequence
2. An additional perfusion CT sequence during the standard contrast-enhanced staging CT
3. Follow Up Length: 36 months
Sponsors
King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with suspected or proven (via optical colonoscopy and biopsy) colorectal cancer attending for pre-operative staging CT 2. Suspicion of colorectal cancer defined as: 2.1. Presence of a mass highly suspicious for colorectal cancer on barium enema, CT colonography or other imaging 2.2. Large bowel obstruction 2.3. Elevated serum CEA 3. Ability to provide informed written consent 4. Aged 18 years or over 5. Male or female participants
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed written consent 2. Pregnancy 3. Renal impairment defined as serum creatinine >1150mmol/L 4. Previous iodinated contrast allergy 5. Inability to cannulate 6. Inability to lie flat 7. Weight greater than 200 kg (maximum weight capacity of CT scanner is 200 kg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To improve the prediction of metastatic disease in patients with colorectal cancer by developing a prognostic model based on disease-free survival 2. Measured at 3 and 5 years for each individual patient | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Scotland, United Kingdom
Outcome results
None listed