Acute kidney injury Urological and Genital Diseases Acute kidney injury
Conditions
Interventions
Patients will be approached for consent pre-operatively either in the pre-assessment clinic or on the day of surgery according to the inclusion and exclusion criteria. Blood samples (approximately 20
Sponsors
Queen Mary University of London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 45 years or over 2. Elective major non-cardiac surgery 3. Anticipated hospital stay of more than 48 hours 4. Prospective written informed patient consent
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. No fixed address or home location outside of 30km of study centre 3. Purely palliative procedure 4. End Stage Renal Disease (Dialysis, pre-dialysis or conservatively managed CKD Stage 5) 5. Known allergy to iodinated radiological contrast agents 6. Unable to consent/lacks capacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate (eGFR) using the CKDEpi creatinine formula at baseline and 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Renal function is measured using serum creatinine based eGFR (CKD-Epi), cystatin c based eGFR (CKDEpi) and Iohexol clearance at baseline, 3 months and 1 year post-operatively 2. Occurence of proteinuria or micro-albuminuria measured at baseline, 3 months and 1 year post-operatively | — |
Countries
United Kingdom
Contacts
Public ContactJohn Prowle
Outcome results
None listed