Oxygen delivery in high-risk surgery Surgery High risk surgery
Conditions
Interventions
Lithium indicator dilution and pulse power analysis is used to measure cardiac output and to calculate Oxygen Delivery Index (DO2I) (LiDCO-plus system). A goal-directed therapy is used during surgery
Sponsors
Faculty of Medicine of Sao Jose do Rio Preto (FAMERP) Foundation (Brazil)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients 2. Either major surgery and one clinical predictor of risk or intermediate risk surgery and the association of two clinical predictors (scoring system adapted from Shoemaker criteria/American College of Cardiology [ACC]/American Heart Association [AHA])
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. Acute myocardial ischaemia less than one month 3. Congestive heart failure (Functional Class IV New York Heart Association [NYHA]) 4. Chronic renal failure (pre-operative creatinine greater than 2.0 mg/dl or need for dialysis) 5. Patients on lithium therapy 6. Severe arrhythmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative complications and hospital/Intensive Care Unit (ICU) length of stay. Primary and secondary outcomes will be measured during the first interim analysis planned that will probably be done in around 2 months (according to the number planned in the project). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Perfusion variables (serum lactate, central venous oxygen saturation) 2. Organ dysfunction Primary and secondary outcomes will be measured during the first interim analysis planned that will probably be done in around 2 months (according to the number planned in the project). | — |
Countries
Brazil
Outcome results
None listed