Patients undergoing second stage revision surgery for previous periprosthetic joint infection (either hip or knee) previously proven with microbiology results Surgery Periprosthetic joint infection (either hip or knee)
Conditions
Interventions
Patients undergoing a second stage revision surgery following periprosthetic joint infection of either hip or knee are identified by their direct care team.
The participant is seen by
Sponsors
Newcastle-upon-Tyne Hospitals Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Undergoing second stage revision surgery following periprosthetic joint infection of either hip or knee 2. Previous periprosthetic joint infection proven with culture results 3. Aged over 18 years
Exclusion criteria
Exclusion criteria: 1. Patient unwilling to consent 2. Patient lacks capacity to consent 3. Patient unable to consent due to communication or language barrier 4. Surgeon unwilling to take intra-operative aspirate sample
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alpha defensin is measured using the Synovasure lateral flow assays at the time of the second stage revision surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The correlation between alpha defensin results and the microbiology culture results is measured using the intra-operative Synovasure result and the final culture result from the intra-operative samples at approximately 5 days post-operatively (once enhanced culture results are available) 2. Variance in the accuracy of alpha defensin in showing effective clearance of a previously infected joint prosthesis according to different patient groups is measured using patient demographics collated from review of medical notes, results and xrays retrospectively from the time that the patient first presented with symptoms leading to the diagnosis of PJI up until their second stage revision surgery | — |
Countries
United Kingdom
Outcome results
None listed