Major abdominal surgery Surgery Abdominal surgery
Conditions
Interventions
In addition to maintenance fluid, control group patients will receive additional 250 ml fluid challenges with colloid solution as required, to achieve a sustained rise in central venous pressure.
In
Sponsors
Queen Mary's University of London (UK)
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients admitted to intensive care or high dependency unit following elective major abdominal surgery
Exclusion criteria
Exclusion criteria: 1. Refusal of consent 2. Concurrent lithium therapy 3. Acute myocardial ischaemia 4. Acute arrhythmias 5. Pregnancy 6. Patients receiving palliative treatment only 7. Weight less than 40 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in post-operative complication rates associated with the use of Goal Directed Therapy. Added as of 23/10/2007: Increase in tissue oxygenation associated with the use of Goal Directed Therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in microvascular perfusion associated with the use of Goal Directed Therapy 2. Reduction in tissue oxygenation associated with the use of Goal Directed Therapy 3. Reduction in post-operative duration of hospital stay associated with the use of Goal Directed Therapy 4. Reduction in post-operative mortality associated with the use of Goal Directed Therapy | — |
Countries
United Kingdom
Outcome results
None listed