Contrast ultrasound study to image the circulation in reconstructive head and neck surgery

A study of power Doppler harmonic imaging in the monitoring of human free-flap tissue perfusion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN94812137

Enrollment

Registered

2009-02-13

Start date

2005-05-19

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Free flap reconstruction for head and neck cancer patients Surgery Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Each participant was monitored by both standard procedures and Power Doppler, as follows: Power Doppler contrast enhanced harmonic imaging was carried out at 12, 24 and 48 hours post-surgery. Standar

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients (both males and females) undergoing head and neck surgery requiring free tissue transfer.

Exclusion criteria

Exclusion criteria: 1. Patients under 18 years 2. Pregnancy and lactation 3. Hypersensitivity to SonoVue® 4. Recent coronary syndrome 5. Ischaemic heart disease 6. Cardiovascular compromise

Design outcomes

Primary

Measure	Time frame
1. Qualitative and quantitative analysis of harmonic imaging at 12, 24 and 48 hours post-surgery 2. Time taken for detection of flap failure compared to standard monitoring within 48 hours post-surgery	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026