Soft Tissue Injuries Injury, Occupational Diseases, Poisoning Soft Tissue Injuries
Conditions
Interventions
Arm 1: Paracetamol 1 g four times daily (qid) and ibuprofen placebo equivalent to 400 mg three times daily (tid)
Arm 2: Paracetamol placebo equivalent to 1 g qid and ibuprofen 400 mg t
Sponsors
Chinese University of Hong Kong (Hong Kong)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients greater than 16 years presenting to the Emergency Department (ED) with isolated soft tissue injury without significant fracture between 9 am to 5 pm, Monday to Friday.
Exclusion criteria
Exclusion criteria: Patients will be excluded if there is: 1. A history of peptic ulceration or haemorrhage 2. Recent anticoagulation 3. Pregnancy 4. Adverse reaction to paracetamol or ibuprofen 5. Renal or cardiac failure 6. Hepatic problems 7. Rectal bleeding 8. Chronic Non-Steriodal Anti-Inflammatory Drug (NSAID) consumption 9. Asthma 10. Chronic obstructive pulmonary disease 11. Chronic pain syndromes 12. Prior treatment with analgesia for the same injury Patients will also be excluded if they have a physical, visual or cognitive impairment making use of the visual analogue scale unreliable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesic efficacy both at rest and with movement at 72 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Presence, frequency and duration of adverse effects at 30 days 2. Cost-effectiveness analysis at 30 days 3. Patient satisfaction with analgesia at 30 days | — |
Countries
Hong Kong
Outcome results
None listed