The influence of surgical interventions with and without cardiopulmonary bypass on Ca2+ signalling in alveolar macrophages

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN94348100

Enrollment

Registered

2007-11-06

Start date

2007-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary dysfunction after surgery Respiratory Postprocedural respiratory disorders

Interventions

Bronchoscopy with Broncho-Alveolar Lavage (BAL) and blood samples before and after surgery. Routine bronchoscopy is used as recommended in a guideline. Duration of treatment is defined by the length o

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Elective coronary bypass graft surgery 2. Elective panendoscopy 3. Elective thoracic surgery

Exclusion criteria

Exclusion criteria: 1. Aged less than 18 years 2. Relevant pulmonary diseases with oxygenation deficit 3. Liver disease stage greater than Child B 4. Human Immunodeficiency Virus (HIV)-infection 5. Corticosteroid therapy 6. Organ transplantation 7. Perioperative infection 8. Chronic inflammatory disease 9. Pregnancy

Design outcomes

Primary

Measure	Time frame
Calcium signal intensity, measured immediately preoperatively and after the surgical procedure.	—

Secondary

Measure	Time frame
Postoperative pulmonary infection, measured on day of discharge.	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026