Aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) Not Applicable Subarachnoid haemorrhage, unspecified
Conditions
Interventions
This prospective observational study will be initiated after obtaining clearance from the institute ethics committee. Written informed consent will be taken from all patients. For patients with altere
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult anterior circulation aneurysmal subarachnoid patients following surgical clipping/coiling and requiring a continuous infusion of noradrenaline in the NICU 2. Adult traumatic brain injury patients following surgery requiring a continuous infusion of noradrenaline in the NICU
Exclusion criteria
Exclusion criteria: 1. Refusal to provide informed consent 2. Pregnant patients 3. Patients with a poor acoustic window on TCD 4. Patients with carotid atheroma 5. Patient with bradycardia and arrhythmia 6. Patients with contraindications to nor-adrenaline infusion, including pre-existing acute renal failure (serum creatinine >2 mg/dl) and ischemia of the digits 7. Patients who underwent decompressive craniectomy 8. Patients receiving more than one vasopressor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Middle cerebral artery (MCA) blood flow velocity and cerebral autoregulation measured using transcranial doppler at baseline, 10% increase and 20% increase in mean arterial blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Regional frontal cerebral oxygenation measured using near infra-red spectroscopy (NIRS) at baseline, 10% increase and 20% increase in mean arterial blood pressure | — |
Countries
India
Outcome results
None listed