Task-related TRAINing in Huntingtons Disease

Task-related TRAINing in Huntingtons Disease: a home-based intervention trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN94284668

Enrollment

Registered

2012-05-24

Start date

2012-07-03

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementias and Neurodegenerative Diseases Mental and Behavioural Disorders Dementia in Huntington's disease

Interventions

Home Based exercise programme, Physiotherapy exercise programme targeted at people with early / mid stage HD. The intervention group is an 8-week (2x/week) programme providing task-related training a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of manifest HD, confirmed by genetic testing 2. Self-reported or physician-reported difficulties with walking and/or balance 3. Between ages of 18 and 70 years 4. Capacity to give informed consent 5. Total functional capacity (TFC) of at least 4 6. Stable medication regime for 4 weeks prior to initiation of trial, and be able to maintain a stable regime for the course of trial 7. Enrolled on EHDN Registry/ENROLL study 8. Target Gender: Male & Female 9. Upper Age Limit 70 years 10. Lower Age Limit 18 years

Exclusion criteria

Exclusion criteria: 1. Hhistory of prior neurological condition, such as stroke 2. Unable to understand or communicate in spoken English 3. Moderate to severe arthritis in the hips, knees or ankles, or orthopaedic condition that limits walking ability 4. Cardiac precautions that would prevent subject from completing the intervention or the full battery of outcomes 5. Currently in receipt of active physiotherapy input 6. Are currently involved in any interventional trial or within 2 months of completing an interventional trial 7. Are not enrolled (or interested in enrolling) on the EHDN Registry/ ENROLL study 8. Demonstrate uncontrolled psychiatric symptoms / have active psychosis

Design outcomes

Primary

Measure	Time frame
Physical Performance Test measured at 0 weeks (baseline), 8 weeks and 16 weeks	—

Secondary

Measure	Time frame
1. 30 second chair stand test measured at 0 weeks (baseline), 8 weeks and 16 weeks 2. 30-second chair stand test by the treating therapists measured at once a week 3. Depression will be quantified by the Hospital Anxiety and Depression Scale (HADS) at 0 weeks (baseline), 8 weeks and 16 weeks 4. Quality of life as measured by the Huntington?s Disease Quality of Life Measure (HD-QOL) measured at 0 weeks (baseline), 8 weeks and 16 weeks 5. The Berg Balance Scale measured at 0 weeks (baseline), 8 weeks and 16 weeks 6. Timed Up and Go walking speed as measured by 10 m walk measured at 0 weeks (baseline), 8 weeks and 16 weeks	—

Measure

Time frame

1. 30 second chair stand test measured at 0 weeks (baseline), 8 weeks and 16 weeks 2. 30-second chair stand test by the treating therapists measured at once a week 3. Depression will be quantified by the Hospital Anxiety and Depression Scale (HADS) at 0 weeks (baseline), 8 weeks and 16 weeks 4. Quality of life as measured by the Huntington?s Disease Quality of Life Measure (HD-QOL) measured at 0 weeks (baseline), 8 weeks and 16 weeks 5. The Berg Balance Scale measured at 0 weeks (baseline), 8 weeks and 16 weeks 6. Timed Up and Go walking speed as measured by 10 m walk measured at 0 weeks (baseline), 8 weeks and 16 weeks

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026