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Efficacy of articaine infiltration for pulp anaesthesia in adult mandibular teeth

Efficacy of articaine infiltration for pulp anaesthesia in adult mandibular teeth: a randomised double-blind cross-over study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN94252698
Enrollment
20
Registered
2009-04-08
Start date
2009-03-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulp anaesthesia in adult mandibular teeth Oral Health Pulp anaesthesia

Interventions

1. Local anaesthetics, average number per participant one injection per visit, average time taken five minutes. All injections will be given by an experienced dentist. 2. Electeric pulp testing: elec

Sponsors

Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy adult volunteers (aged 18 years or older, either sex) 2. Staff or students at Newcastle University

Exclusion criteria

Exclusion criteria: The volunteer: 1. Individuals under 18 years old 2. Systemic disorders which may place volunteers at risk from local anaesthetic injection for example bleeding disorders, history of infective endocarditis, pregnant women 3. Allergies to local anaesthetic drugs 4. Facial anaesthesia or paraesthesia 5. In dental pain at the time of the trial 6. Individuals unable to give informed consent The teeth to be included: 1. Teeth which respond negatively to baseline pulp testing 2. Key test teeth missing

Design outcomes

Primary

MeasureTime frame
Numbness of lower anterior and posterior teeth (front and back teeth) following local anaesthetic injection; measured from one minute after the injection of local anaesthetic solution until 47 minutes.

Secondary

MeasureTime frame
Injection discomfort (recorded immediately after injection) and duration of numbness after injection of anaesthetic solution (measured from one minutes after injection until 47 minutes).

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026