Respiratory failure in preterm infants requiring mechanical ventilation Neonatal Diseases Respiratory failure of newborn
Conditions
Interventions
This randomized crossover trial involved preterm infants who are mechanically ventilated and receiving supplemental oxygen. Each infant was studied for two consecutive 12-hour periods, one with inspir
Sponsors
South Tees Hospital NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Preterm infants were enrolled in the study if they met all of the following inclusion criteria: 1. Written informed parental consent 2. Receiving mechanical ventilation through an endotracheal tube 3. On supplemental oxygen at the time of enrolment and during the previous 24 hours 4. Without major congenital anomalies
Exclusion criteria
Exclusion criteria: 1. Major congenital anomalies 2. Not requiring supplemental oxygen during the previous 24 hours prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of time with pulse oximetry (SpO2) within the assigned target range of 90-95% during two consecutive 12-hour periods of automated and manual adjustment of inspired oxygen (FiO2). | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of time with pulse oximetry (SpO2) outside of the assigned target range of 90-95%, extreme hypoxemia (<80%) and hyperoxemia (=98%) during two consecutive 12-hour periods of automated and manual adjustment of inspired oxygen (FiO2). | — |
Countries
United Kingdom
Contacts
Public ContactMithilesh Lal
Outcome results
None listed