Cluster headache Nervous System Diseases Cluster headache
Conditions
Interventions
Treatment of acute cluster headache with inhaled air or oxygen. Each participant will be randomised to treatment sequence of either AB or BA, where A is oxygen and B is inhaled air.
Sponsors
BOC Ltd (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Active Cluster headache 2. Attack duration between 45 minutes and three hours
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women will be excluded 2. Patients with moderate to severe chronic obstructive pulmonary disease will be excluded as the high-dose high-flow oxygen may affect their hypoxic respiratory drive. 3. Patients who cannot tolerate the oxygen mask in the correct fitting will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients pain free after 15 minutes of treatment comparing oxygen and air. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rendering the patient pain free at 30 minutes 2. Reduction in pain scale at 15, 30, 45 and 60 minutes 3. Need for rescue medication from 15 minutes after treatment 4. Overall response to the treatment and overall functional disability 5. Effect on associated symptoms | — |
Countries
United Kingdom
Outcome results
None listed