Short term effect of a hazelnut skin drink on the health of blood vessels

An exploratory study profiling secondary polyphenol metabolites and acute modulation of vascular function following ingestion of a hazelnut extract based drink

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN93825268

Enrollment

Registered

2016-07-20

Start date

2016-03-07

Completion date

Unknown

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular and endothelial function Circulatory System

Interventions

Participants attend two study visits at which they drink 238ml of a placebo drink (visit one) or 1% hot water infusion of powdered hazelnut skin (visit two). The washout period between the two visits

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy men and women 2. BMI between 18.5-25kg/m² 3. Aged between 18-65 years

Exclusion criteria

Exclusion criteria: 1. All diagnosed cardiovascular risk factors or disorders such as history of myocardial infarction, acute coronary syndromes, stroke or transient ischaemic attacks, intermittent claudication, rheumatoid arthritis or inflammatory diseases 2. Diabetes and disorders of glycaemic control 3. Irritable and inflammatory bowel disorders and acid peptic disease 4. Any active tumours / cancers with poor prognosis 5. Current active mental illness 6. Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) 7. Smoking 8. Nut allergies or intolerances and any other relevant food allergies 9. Lipid or cholesterol lowering tablets 10. High dose aspirin and analogues >100mg/ day 11. Sustained use of nutritional supplements and/ or prescription medication including any hormonal/ contraceptive preparation, likely to impact on study measurements or safety

Design outcomes

Primary

Measure	Time frame
Endothelial function is measured by flow mediated dilatation (FMD) pre-ingestion of the study drink and then 1.5 and 3.5 hours post drink ingestion and EndoFMS using Vicorder pre-ingestion of the study drink and then 4.5 hours post drink ingestion at each study visit.	—

Secondary

Measure	Time frame
1. Pattern of appearance of secondary phenolic metabolites in plasma (pre-ingestion of the study drink and then 1.5, 3 and 4.5 hours post drink ingestion) and urine (pre-ingestion of the study drink and then 0-5, 5-7, 7-10, 10-24, 24-28, 28-34 and 34-48 hours post drink ingestion) at each study visit 2. Vascular smooth muscle function are measured using Sphygmocor applanation tonometry and the Vicorder systems pre-ingestion of the study drink and then 1.5 and 3.5 hours post drink ingestion at each study visit	—

Measure

Time frame

1. Pattern of appearance of secondary phenolic metabolites in plasma (pre-ingestion of the study drink and then 1.5, 3 and 4.5 hours post drink ingestion) and urine (pre-ingestion of the study drink and then 0-5, 5-7, 7-10, 10-24, 24-28, 28-34 and 34-48 hours post drink ingestion) at each study visit 2. Vascular smooth muscle function are measured using Sphygmocor applanation tonometry and the Vicorder systems pre-ingestion of the study drink and then 1.5 and 3.5 hours post drink ingestion at each study visit

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026