Cannabis elicited psychopathology and cognitive impairment Mental and Behavioural Disorders Mental and behavioural disorders due to use of cannabinoids
Conditions
Interventions
Delta-9-tetrahydrocannabivarin (THCV) 10 mg per day for 5 days or matched placebo.
Sponsors
King's College London (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy male volunteers aged 21-35 who have used cannabis not more than 25 times
Exclusion criteria
Exclusion criteria: 1. History (or family history) of mental illness (including any psychotic disorder, depression/anxiety) 2. Major physical illness, 3. Previous treatment with psychotropic medicines and drug/alcohol addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores on the following cognitive tasks: 1. The Hopkins Verbal Learning Task 2. Digit-span 3. The time estimation task Psychotic symptoms: 1. The Community Assessment of Psychic Experiences (CAPE) scale 2. The Self Assessment Module (SAM) scale Measures will be taken at baseline, post THCV/placebo and post THC over the course of 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores on the following scales of psychopathology: 1. The Mood Adjective Check List 2. Beck?s Anxiety Inventory 3. Visual Analogue Scales 4. The State Social Paranoia Scale Measures will be taken at baseline, post THCV/placebo and post THC over the course of 5 days | — |
Countries
United Kingdom
Outcome results
None listed