Schizophrenia Mental and Behavioural Disorders Schizophrenia
Conditions
Interventions
12 patients will be randomly assigned to three different treatment conditions:
1. Prefrontal stimulation
2. Cerebellar stimulation
3. Placebo (sham) stimulation
Magnetic stimulation (TBS) will occur
Sponsors
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients with schizophrenia (ages 18-55 years) 2. Patients will be screened with the Schedule for the Assessment of Negative Symptoms (SANS) (Andreasen, 1983). Patients with severe negative symptoms (defined by score of = 3 in any of SANS sub-scales) will be recruited for this study 3. All participants will be assessed for intelligence using the NART (Nelson, 1991) and handedness with Edinburgh Handedness Inventory (Oldfield, 1971)
Exclusion criteria
Exclusion criteria: 1. History of neurological disorder including seizures 2. General medical conditions likely to impair cortical function or haemodynamic response (hypertension or diabetes) 3. Metallic implants (and other contraindications to MR procedures) 4. Established drug or alcohol dependency disorders 5. Estimated IQ less than 75 6. Inability to give an informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional functional brain response measured with functional magnetic resonance imaging (fMRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| A variety of standardised psychiatric ratings and neuropsychological tests | — |
Countries
United Kingdom
Outcome results
None listed