Chronic diseases, particularly cardiovascular disease and cancers Not Applicable
Conditions
Interventions
Volunteers were stratified by age and sex and randomly assigned into the test or control group:
1. Test group: 3 x high-bran products per day for 4 weeks (1 x ready-to-eat cereal + 2 x bread products)
Sponsors
European Commission (Belgium)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy men and women aged between 45 - 65 years 2. Body Mass Index (BMI) greater than 25 kg/m^2 This inclusion criteria were selected as such individuals are thought to be at a slightly greater risk of chronic disease.
Exclusion criteria
Exclusion criteria: 1. Smokers 2. People on special diets (e.g. vegetarians, coeliac patients) 3. People with diabetes 4. Pre-existing chronic disease 5. Regular use of prescription medicine, including statins and blood pressure medication 6. People who regularly take any vitamin or mineral supplement or have done so in the last 6 months 7. Women who are pregnant or lactating 8. People who have given blood to the blood transfusion service (BTS) within the past 4 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in plasma homocysteine (a risk marker for CHD) attributable to treatment during the intervention, measured at baseline and 4 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in other risk markers for disease attributable to treatments during the intervention: 1. Inflammatory markers and endothelial function 2. Antioxidant status 3. Lipid profile 4. Relevant micronutrient levels 5. Insulin and glucose levels Outcomes measured at baseline and 4 weeks. | — |
Countries
United Kingdom
Outcome results
None listed