Efficacy of Collagen supplementation in improving skin quality and reducing the signs of skin aging. Skin and Connective Tissue Diseases
Conditions
Interventions
The study is a human research study in which customers that are taking the collagen activator from Avea are observed for six months. The trial is in the form of a post marketing surveillance observati
Sponsors
Avea Life AG
Eligibility
Sex/Gender
All
Age
35 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 35 or older, regardless of gender, ethnicity or socioeconomic background 2. Voluntarily purchasing the collagen activator (from Avea) for 6 months with the intend to take it on a daily basis 3. Willing to fill out the questionnaires on a monthly basis. 4. Willing to participate in all measurements part of the study (Skin tests & saliva samples) 5. Able to appear at the baseline, 1 and 3 months follow-up visits at the Dermatology clinic “Hautwerk” in Zürich
Exclusion criteria
Exclusion criteria: 1. Underlying health conditions leading to regular intake of medication, including: 1.1. Diabetes 1.2. Hypertension (high blood pressure) 1.3. Cardiovascular disease 1.4. Asthma 1.5. Chronic obstructive pulmonary disease (COPD) 1.6. Arthritis 1.7. Depression 1.8. Anxiety 1.9. Epilepsy 1.10. Cancer 1.11. Thyroid disorders 1.12. Autoimmune diseases (e.g., lupus, multiple sclerosis) 1.13. Chronic kidney disease 1.14. Liver disease 1.15. HIV/AIDS 1.16. Chronic pain conditions (e.g., fibromyalgia, chronic migraine) 2. Chronic skin conditions, independent of treatment, including: 2.1. Acne 2.2. Eczema 2.3. Psoriasis 2.4. Rosacea 2.5. Skin cancer 3. Intake of any collagen supplements within 3 months prior to the screening date 4. Smoking at the time of recruitment or within 5 years prior 5. Pregnancy or lactating at the time of recruitment, or planning pregnancy within the next 6 months 6. Insufficient knowledge of the German or English language 7. Inability to give consent 8. Inability to follow study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in DNA methylation patterns as a biomarker of biological age using TruMe DNA test at Baseline and Month-6. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hydration, measured using the corneometer at Baseline, Month-1, and Month-3. 2. Elasticity, measured using the cutometer at baseline, Month-1, and Month-3 3. Skin thickness and density, measured using the ultrascan at baseline, Month-1, and Month-3. 4. Pigmentation, wrinkles, texture, UV-spots, pores, redness, and porphyrins, measured usign the Visia scan at baseline, Month-1, and Month-3. These measurements contribute to determining skin quality and texture by providing objective and quantitative data on various aspects of the skin. By monitoring changes in these measurements over time, researchers can assess the effectiveness of the collagen activator aimed at improving skin quality and texture. | — |
Countries
Switzerland
Contacts
Public ContactSophie Chabloz
Outcome results
None listed