Bioavailability of virgin olive oil bioactive compounds and medium term impact on biomarkers of health

Bioavailability of virgin olive oil bioactive compounds and impact of a 6-week supplementation on biomarkers of coronary artery disease, chronic kidney disease or diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN93136746

Enrollment

Registered

2014-07-09

Start date

2012-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Risk of coronary artery disease, chronic kidney disease and diabetes Nutritional, Metabolic, Endocrine

Interventions

66 healthy volunteers will be randomly allocated into one of two groups and asked to consume 20 ml of olive oil per day for 6 weeks. Group 1 will be given olive oil with a high polyphenolic content.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults, aged 18-75 years

Exclusion criteria

Exclusion criteria: 1. Those allergic to olive products 2. Currently taking medication (other than the contraceptive pill) 3. Have taken antibiotics in the last 3 months 4. Have received or are receiving treatments for any chronic gut disease 5. Is pregnant, trying to conceive, or lactating

Design outcomes

Primary

Measure	Time frame
Proteomic urinary biomarkers of coronary artery disease, chronic kidney disease and diabetes. These will be measured after 3 weeks, the mid point and after 6 weeks, the end of the study.	—

Secondary

Measure	Time frame
Plasma-based biomarkers of heart disease and blood pressure. These will be measured after 3 weeks, the mid point and after 6 weeks, the end of the study.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026