Effects of a combined exercise therapy on physical condition, muscle strength, quality of life and serum profiles in type 2 diabetes mellitus

A randomised controlled trial investigating the effects of 12 weeks of combined aerobic and resistance exercise program on serum profiles, functional capacity, isokinetic muscle strength and quality of life type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN93104189

Enrollment

Registered

2010-04-29

Start date

2008-09-10

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type II diabetes mellitus Nutritional, Metabolic, Endocrine Non-insulin-dependent diabetes mellitus

Interventions

The supervised exercise therapy consisted of 1 hour-session for 3-times/week and for 12-weeks. Each session included 1. 10 minutes of warming up with slow walks and easy movements of progressive inte

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Non-smokers and not consumers of alcohol 2. Either sex 3. Age between 30 and 70 years 4. At least 3 years with diagnosed type-2 diabetes mellitus

Exclusion criteria

Exclusion criteria: Presence of any disorders that might prevent physical training load and require other psychological, physical or nutritional therapy

Design outcomes

Primary

Measure	Time frame
The primary endpoint with respect to efficacy of the combined exercise therapy in type-2 diabetes patient was to produce a moderate decrease in serum glycated hemoglobine (HbA1c) levels. Therefore, this parameter was measured from fasting blood samples along others, such as fasting glucose, HDL and LDL cholesterol, triglycerides, alanino aminotransferase (ALT) and aspartate aminotrasnferase (AST) in a standardized manner at laboratories of the hospital of the city of Évora (Portugal). Measurements were made at baseline and post-intervention at 12 weeks.	—

Measure

Time frame

The primary endpoint with respect to efficacy of the combined exercise therapy in type-2 diabetes patient was to produce a moderate decrease in serum glycated hemoglobine (HbA1c) levels. Therefore, this parameter was measured from fasting blood samples along others, such as fasting glucose, HDL and LDL cholesterol, triglycerides, alanino aminotransferase (ALT) and aspartate aminotrasnferase (AST) in a standardized manner at laboratories of the hospital of the city of Évora (Portugal). Measurements were made at baseline and post-intervention at 12 weeks.

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Secondary

Measure	Time frame
1. Muscle condition: maximal peak force of the knee extensors and flexors was recorded by using the Biodex System-3 Isokinetic Dynamometer (Biodex Corp., Shirley, NY, USA). Each subset performed biolateral tests of maximal isokinetic leg strength and leg muscle fatigue. 2. Health-related quality of life (HRQOL), measured using the Portuguese language version of the Short Form 36 Health Survey (SF-36) 3. Body composition: percentage fat, total and abdominal, were assessed using dual-energy X-ray absorptiometry (DXA, Norland Excell Plus, Norland Inc, Fort Atkinson, USA) 4. Functional capacity of the patients, assessed by several tests, performed in a standardized manner: 4.1. Maximal walking speed test over 10 metres 4.2. 10-stairs climbing test 4.3. 10-stairs climbing test carrying a bag weighing 5 kg in each hand 4.4. Timed up and go test 4.5. 30 seconds chair stand test 4.6. 6-minutes walking test Measurements were made at baseline and post-intervention at 12 weeks.	—

Measure

Time frame

1. Muscle condition: maximal peak force of the knee extensors and flexors was recorded by using the Biodex System-3 Isokinetic Dynamometer (Biodex Corp., Shirley, NY, USA). Each subset performed biolateral tests of maximal isokinetic leg strength and leg muscle fatigue. 2. Health-related quality of life (HRQOL), measured using the Portuguese language version of the Short Form 36 Health Survey (SF-36) 3. Body composition: percentage fat, total and abdominal, were assessed using dual-energy X-ray absorptiometry (DXA, Norland Excell Plus, Norland Inc, Fort Atkinson, USA) 4. Functional capacity of the patients, assessed by several tests, performed in a standardized manner: 4.1. Maximal walking speed test over 10 metres 4.2. 10-stairs climbing test 4.3. 10-stairs climbing test carrying a bag weighing 5 kg in each hand 4.4. Timed up and go test 4.5. 30 seconds chair stand test 4.6. 6-minutes walking test Measurements were made at baseline and post-intervention at 12 weeks.

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Countries

Portugal

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026